The three chief types of lipotropic factors which prevent or remove an excess accumulation of fat in the liver are choline, lipocaic and inositol. Choline appears to act by promoting the formation of phospholipins of the lecithin type, and may under certain circumstances be replaced by methionine which, in the presence of ethanolamine, supplies the necessary methyl groups for choline synthesis.
Inositol is a lipotropic factor for the rat. Its action may be due to promotion of phospholipin formation. Alterations in the vitamin B group content of the diet may alter a fatty liver so that it resists the action of choline but responds to inositol. [Source]
The Lipotropic Properties of Inositol
Inositol was found in numerous experiments with rats to be no more active than choline, and usually less active, in correcting the excessive deposition of fat and cholesteryl esters in the liver, whether the deposition was induced by injection of biotin or by other means.
It is pointed out that the comparison of the effects of choline and inositol in correcting fatty livers induced by administration of liver extracts may be complicated by the presence of choline in the extract.
Since choline and inositol act synergistically it might be unfair to compare the lipotropic effect of inositol added to existing choline as compared with extra eholine added to choline.
Inositol was ineffective in preventing the occurrence of haemorrhagic kidneys in rats kept on a diet deficient in choline and methionine. [Source]
The Effect of Other Lipotropic Substances on the Fate of Choline after Oral and Intravenous Administration
The intravenous injection of methionine, inositol, and choline in relatively large amounts is well tolerated and appears to be without danger. [Source]